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Everything about ceesdekker.net
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Human Rad51 filaments on double- and one-stranded DNA: correlating typical and irregular varieties with recombination function.
[Laughs] ‘It had been undoubtedly a fantastic threat! At time, I was well aware that it could go wrong Which I could develop into a lot less profitable, but I just overlooked that. Curiosity has constantly been my strongest driving power. And luckily it all labored out.’
Considering the fact that 2000, Dekker has shifted the key concentration of his function toward biophysics where he scientific studies the Houses of one biomolecules and cells using the equipment of nanotechnology. This alteration of field was driven by his fascination to the amazing performing of biological molecular structures, and also because of the long-term viewpoint that lots of appealing discoveries is usually expected Within this area.[5] Recent strains of investigate in his biophysics team are in the areas of:[6]
This yielded a breakthrough. Within just only a few months, we were being capable to evaluate transport through someone one-walled carbon nanotube. Determined by low-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Engineering having an active investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being genuine quantum wires with incredibly lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Our analysis ranges from your biophysics of DNA to artificial cells cees dekker and outside of. You should take a look under on the spectrum of our existing tasks.
Several relevant developments adopted, the place our team recognized unique transistor variants which include single-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled many transistors into compact evidence-of-theory electronic circuits.
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
In 1993, for a young and eager affiliate professor at Delft College of Engineering, I'd in the beginning focused the investigation initiatives of my team on measuring the electrical conductance of a single conducting-polymer molecule. In two decades, we had produced a device where a single wire of a phthalocyaninepolysiloxane polymer was connected amongst two intently spaced metallic nanoelectrodes.
But carbon nanotubes have remained a analysis subject of significant curiosity to several. Certainly, the outlook on utilizing carbon nanotubes to construct sensible devices, in areas such as radio-frequency electronics, electronic electronics and versatile electronics, remains brilliant.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
‘That considerations the artificial cell, as Section of the Dutch BaSyC initiative. Craig Venter appeared best-down in Those people days and determined about 5 hundred genes which are minimally expected to get a operating mobile. We want to search base-up: how can we transfer from the couple molecules to a complete biological process?
Visualization of unstained DNA nanostructures with State-of-the-art in-aim transmission electron microscopy methods
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments